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The BMJ retracts clinical trial for ‘severe’ discrepancies in randomization


The study, published in July 2024, reports the results of a trial comparing intravenous and intraosseous vascular access for treating people who experienced cardiac arrest. The December 18, 2025 retraction notice references an online comment that “raised concerns about the randomisation scheme and allocation ratio” in the study.

In his comment on the article, Lars Andersen, who is also a statistical reviewer for the Journal for the American Medical Association, noted the randomization of the interventions and the ratio of patients in each treatment group did not occur in the same ratio the authors had specified.

The authors “launched an exhaustive one-month re-examination” of the data, Wen-Chu Chiang (author of the paper) said, and confirmed some of the data “did not strictly adhere to the schedule due to unprecedented disruptions to our research operations during the pandemic.” The authors requested a retraction and replacement or a correction of the article, but “fully respect” the decision to retract.

Source https://retractionwatch.com/2025/12/29/bmj-retraction-clinical-trial-discrepancies-randomization/

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